Published on:June 2017
International Journal of Pharmacology and Clinical Sciences, 2016; 5(4):103-108
Original Article | doi:10.5530/ijpcs.5.4.2

Short term Toxicity Profile of ethanol extract of Solanum erianthum leaf in Rats


Authors and affiliation (s):

Ramya URS, Lakshmidevi* N

*DOS in Microbiology, University of Mysore, Manasagangothri, Mysore, Karnataka, INDIA.

Abstract:

Introduction: Solanum erianthum is medicinal plant used by folklore all over the world. There is no studies conducted on the toxicological effect of the plant. The present study aims to evaluate the toxicological effect of methanol extract of the leaf of the plant. Methods: The Solanum erianthum leaf was evaluated for toxic effects in Sprague Dawley rats. The extract was given in three doses (125,250,500 mg/kg BW of rats) for 14 days and the effect of the extract on the behaviour and normal physiology was assessed. Results: There was no mortality caused in any of the dosage groups. It was observed that the extract not has affected the normal behaviour and caused no deleterious effect on normal physiology, at all the doses given. Extract has no effect on pattern of weight gain and was comparable to normal control group. Serum biochemical parameters also were not altered and were comparable to normal control group. Conclusion: The results and observations of study it can be proposed that the extract has no mortality and is completely non toxic to the animal system.

Key words: Solanum erianthum, 14 days repeated-dose toxicity profile, Hepatic enzymes, Histopathology, Safety profile.

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