Background: Oxidative free radicals induce gastric injury in animal models of peptic ulcer. Hence antioxidants may provide gastroprotection. Objectives: The present study was undertaken to evaluate the gastroprotective role of antioxidant alpha-tocopherol in indomethacin induced gastric ulceration in albino rats. Materials and methods: Animals were diveded into 3 groups (n=6) group 1 (control which received distilled water), group11 (alpha-tocopherol 12.5 mg/kg) and group 111 ( omeprazole 3.6 mg/kg). Each group received the corresponding 4 hours, animals were sacrificed and their stomachs were studied for ulcerationm, adherent mucin content, and ulcer index was calculated. The results of alpha-tocopherol were compared with those of control and omeprazole treated groups and data was analyzed manually using Student t test. A p Value of < 0.05 was considered as satistically significant. Results: Alpha-tocopherol administrative reduce ulceration and ulcer index compared to control group (t cal5.2>tab 2.23 at 5% level of significance, p<0.05). Omeprazole treatment also reduced ulcer index and ulceration in comparison to control group (tcal 6.2>ttab 3.16 at 1% level of significance, p<0.01). Thus results of test drug were similar to omeprazole treated group. Conclusion: Alpha-tocopherol treatment provides gastroprotection in indomethacin induced gastric ulceration.
Key words: Indomethacin, alpha-tocopherol, antioxidant, gastroprotection.