Published on:2012
International Journal of Pharmacology and Clinical Sciences, 2012; 1(3):79-81
Research Article | doi:Nill

In-vitro alpha-glucosidase inhibitory activity of abraga chendhooram, a Siddha drug


Authors and affiliation (s):

R. Sathish1, R. Madhavan2, Hannah R. Vasanthi 3, Arul Amuthan4*

1Department of Toxicology, Sri Sairam Siddha Medical College, Chennai, India

2Department of Toxicology, National Institute of Siddha, Chennai, India

3Herbal and Indian Medicine Research Laboratory, Department of Biochemistry, Sri Ramachandra University, India

4Department of Pharmacology, Melaka Manipal Medical College, Manipal University, India

Abstract:

The present study was carried out to evaluate alpha-glucosidase inhibitory activity of abraga chendhooram which is a Siddha drug being used to treat diabetes mellitus. The ingredient of abraga chendhooram includes biotite (K(Mg,Fe)3AlSi3O10(F,OH)2), Sesbania grandiflora, Calotropis gigantea and Momordica charantia. In-vitro alpha-glucosidase inhibitory assay was performed by standard procedure. Different concentrations of abraga chendhooram and miglitol (standard drug) were used. Abraga chendhooram exhibited a dose dependent alpha-glucosidase inhibitory activity, but it was less than standard drug. Further studies are warranted to look other possible mechanisms for its antidiabetic claim and to assess its safety

Key words: Ayurveda, diabetes mellitus, herbo-metallic, biotite, abraga, mica, basma

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