Background: It is estimated that about 12% of men and 55% of women have at least one episode of kidney stone during their life time. The incident in general population is about 1 in 1000 adults per year. Objectives: The present study was done to evaluate the nephroprotective effect of ethanolic extract of roots and oleanolic acid (OA) isolated from roots of Lantana camara (L. camara) Materials and methods: The nephroprotective effect of different concentrations of oleanolic acid (60 mg/kg, 80 mg/kg and100 mg/kg) and ethanolic extracts of roots of L. camara (ELC) at a dose of 200 mg/kg was assessed in albino Wistar male rats using gentamicin induced nephrotoxicity model. The parameters studied were urine volume, serum creatinine, urine creatinine, serum albumin, urine albumin, serum blood urea nitrogen, serum urea, urine blood urea nitrogen, urine urea, weight of kidney, body weight and glomerular filtration rate (GFR). Statistical analysis was performed by Dunnett’s Multiple Comparison test. All values were represented as Mean ± SEM. A p value < 0.05 was considered as statistically significant. Results: Urine creatinine, serum creatinine, blood urea, blood urea nitrogen, serum albumin, urine albumin and weight of rat kidneys were found to be increased in rats treated with gentamicin, but these indicators of nephrotoxicity were normalized in OA (p < 0.001) and ELC (p < 0.05) treated rats in a dose dependent manner. Reduced level of GFR in gentamicin treated group was also normalized by OA and ELC treated groups in a dose dependent manner. Conclusion: The result of the above study concludes that the OA showed promising nephroprotective activity in dose dependent manner. These results suggest the therapeutic utility of OA in renal injury.
Key words:Lantana camara, nephroprotective activity, oleanolic acid, gentamicin.