International Journal of Pharmacology and Clinical Sciences, 2013, 2, 4, 126-128.
Published: December 2013
Type: Case Report
Authors: R. Dinesh Prabhu, G. Vikneswaran, Chultin Lepcha, and N. Tombi Singh
Author(s) affiliations:
R. Dinesh Prabhu1, G. Vikneswaran2*, Chultin Lepcha1, N. Tombi Singh3
1Post Graduate, Department of Respiratory Medicine, Regional Institute of Medical Sciences, Imphal , Manipur, India.
2Post Graduate, Department of Pharmacology, Regional Institute of Medical Sciences, Imphal , Manipur, India.
3Professor, Department of Respiratory Medicine, Regional Institute of Medical Sciences, Imphal , Manipur, India.
Abstract
Thrombocytopenia is a rare adverse effect seen with anti-tubercular drugs. We report an 80 year old male with tubercular right pleural effusion, on Category I Anti-tubercular therapy (ATT) for 3 weeks who presented with melena and epistaxis. On evaluation, he had thrombocytopenia which was found to be rifampicin-induced. ATT was restarted without rifampicin and there were no bleeding episodes. Though, rifampicin is well tolerated, but on rare occasions it can cause thrombocytopenia.