Short-term Toxicity Profile of Ethanol Extract of Solanum erianthum Leaf in Rats

Ramya URS, Lakshmidevi N

DOS in Microbiology, University of Mysore, Manasagangothri, Mysore, Karnataka, INDIA.

Introduction: Solanum erianthum is a medicinal plant used by folklore all over the world. There have been no studies conducted on the toxicological effects of the plant. The present study aims to evaluate the toxicological effect of methanol extract of the leaf of the plant. Methods: The Solanum erianthum leaf was evaluated for toxic effects in Sprague Dawley rats. The extract was given in three doses (125, 250, 500 mg/kg BW of rats) for 14 days, and the effect of the extract on behavior and normal physiology was assessed. Results: There was no mortality observed in any of the dosage groups. It was observed that the extract did not affect normal behavior and caused no deleterious effects on normal physiology at all the doses given. The extract had no effect on the pattern of weight gain and was comparable to the normal control group. Serum biochemical parameters also were not altered and were comparable to the normal control group. Conclusion: The results and observations of the study suggest that the extract has no mortality and is completely non-toxic to the animal system.

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