Adverse Drug Reaction Monitoring of Antipsychotic Drugs and Mood Stabilizers in a Teaching Hospital

International Journal of Pharmacology and Clinical Sciences, 2016, 5, 4, 118-121.
DOI: 10.5530/ijpcs.5.4.5
Published: December 2016
Type: Research Article
Authors: Swetha Munoli, Soumya B Patil
Author(s) affiliations:

Swetha Munoli1, Soumya B Patil2*

1Department of Pharmacology, ESIC-MC and PGIMSR, Bangalore, Karnataka, INDIA.

2Department of Pharmacology, Navodaya Medical College, Raichur, Karnataka, INDIA.

Abstract

Background: Antipsychotics and mood stabilizers are associated with adverse effects which can affect compliance and the course of treatment in mental disorders. The present study was undertaken to monitor the adverse drug reactions (ADRs) of antipsychotics and mood stabilizers in the psychiatric outpatient unit of our hospital. Methods: The study was conducted from December 2011 to November 2012. Patients on antipsychotic drugs from the psychiatry outpatient department (OPD) of Raichur Institute of Medical Sciences were considered for analysis. The patients were diagnosed by a consultant psychiatrist. Data were collected in a standard questionnaire format. All patients diagnosed with psychiatric disorders as per ICD 10 criteria and receiving treatment with antipsychotics or mood stabilizers were included. Assessment of causality and severity of recorded adverse events was done using the WHO assessment scale and modified Siegel and Hartwig Scale, respectively. Results: Forty-five ADRs were recorded among 778 patients. Extrapyramidal symptoms, anticholinergic side effects, and weight gain were the most common ADRs. Risperidone, chlorpromazine, and olanzapine were the drugs causing the maximum ADRs. Assessment of causality and severity of recorded adverse events showed possible to probable and mild to moderately severe, respectively. Conclusion: Extrapyramidal symptoms were the most common ADRs in our study followed by anticholinergic side effects. Risperidone was the most commonly prescribed drug followed by chlorpromazine. Risperidone and chlorpromazine accounted for most of the ADRs. Assessment of the causality of recorded adverse events showed no certain cause, and assessment of the severity of recorded adverse events showed no severe cases.

Keywords: Antipsychotics, Extrapyramidal Symptoms, Haloperidol, Lithium, Olanzapine, Risperidone


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